YMDD motif mutations in chronic hepatitis B antiviral treatment naïve patients: a multi-center study
نویسندگان
چکیده
منابع مشابه
Frequency of YMDD mutations in patients with chronic hepatitis B untreated with antiviral medicines
Abstract Background: Investigators were suspicious of tyrosine-methionine-aspartate-aspartate (YMDD) mutations occurred only in patients who were treated by lamivudine. However, YMDD mutations of hepatitis B virus gene (HBV DNA) in patients with chronic hepatitis B (CHB) untreated with antiviral medicines was reported in some studies. The aim of this study was to evaluate YMDD mutations in Ira...
متن کاملYMDD and FLLAQ Mutations in Chronic Hepatitis B Patients
Abstract Background and Objective: Lamivudine is the first orally available drug approved for treatment of chronic hepatitis B. Mutations at the YMDD and FLLAQ motifs in the domains of HBV polymerase gene contribute resistance to lamivudine. This study was aimed to determine the rate of YMDD and FLLAQ mutants in hepatitis B patients in Golestan Province, Iran. Material and methods: In this cros...
متن کاملNatural YMDD motif mutations in treatment naïve patients with chronic hepatitis B in Huzhou of eastern China.
amivudine (LAM), a nucleoside analog, was the first anti-HBV rug approved for antiviral therapy in China. Long-term antivial therapy with LAM may lead to drug resistance, which is ssociated with a mutation in tyrosine-methionine-aspartic cid-aspartic acid (YMDD) motif of the reverse transcripase in HBV-DNA genome. Several previous studies showed hat YMDD mutations were also present in treatment...
متن کاملYMDD mutations in patients with chronic hepatitis B untreated with antiviral medicines.
AIM To polymerase P region (YMDD) mutations of hepatitis B virus gene (HBV DNA) in patients with chronic hepatitis B (CHB) untreated with antiviral medicines and to explore its correlation with pre-c-zone mutations, HBV genotypes and HBV DNA level, and to observe its curative effect. METHODS A total of 104 cases (38 cases in group of familial aggregation and 66 cases in group of non-familial ...
متن کاملfrequency of ymdd mutations in patients with chronic hepatitis b untreated with antiviral medicines
abstract background: investigators were suspicious of tyrosine-methionine-aspartate-aspartate (ymdd) mutations occurred only in patients who were treated by lamivudine. however, ymdd mutations of hepatitis b virus gene (hbv dna) in patients with chronic hepatitis b (chb) untreated with antiviral medicines was reported in some studies. the aim of this study was to evaluate ymdd mutations in iran...
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ژورنال
عنوان ژورنال: Brazilian Journal of Infectious Diseases
سال: 2012
ISSN: 1413-8670
DOI: 10.1590/s1413-86702012000300006